Aida Delgado

The paper shows that increasing GCase activity reduces Tau accumulation in fibroblasts with GBA1 mutations, suggesting it could be a therapeutic strategy for neurodegenerative diseases.

This paper develops two allosteric GCase correctors that improve folding and lysosomal function in GD patient fibroblasts, reducing cellular stress and offering potential therapy for GD, PD, and Dementia with Lewy Bodies.