Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT+ ILC2 state linked to immune disease susceptibility
Simone E. M. Olsthoorn, Anne Onrust-van Schoonhoven, Marjolein J. W. de Bruijn, Jochem Weekers, Menno van Nimwegen, Gregory van Beek, Willem de Koning, Lianne Trap, Esmee K. van der Ploeg, Geert H. van Weelden, Mathijs A. Sanders, Laura Surace, James P. Di Santo, Rudi W. Hendriks, Ralph Stadhouders
This study identifies KIT+ ILC2s as an epigenomically plastic state linked to immune disease susceptibility and shows that STAT5 activation by cytokines induces this phenotype.
Journal of Allergy and Clinical Immunology · Jun 17, 2026Peer-reviewedImmunology