EBNA1 INHIBITORS REVEAL CDC7 AND POU2F1 AS DIRECT FUNCTIONAL TARGETS IN EBV EPITHELIAL CANCERS
Songtao He, Niseno Terhuja, Samantha S. Soldan, Christopher Chen, Joel Cassel, Xiangfan Yin, Qin Liu, Sun Sook Chung, Leonardo Josué Castro-Muñoz, Leena Yoon, J. Wang, Joseph M. Salvino, Benjamin E. Gewurz, Italo Tempera, Troy E. Messick, Paul M. Lieberman
This study identifies CDC7 and POU2F1 as direct targets of EBNA1 in EBV+ epithelial cancers using VK1727 inhibition, revealing new therapeutic strategies.
mBio · May 14, 2026Peer-reviewedMicrobiology