Joseph M. Salvino

EBNA1 INHIBITORS REVEAL CDC7 AND POU2F1 AS DIRECT FUNCTIONAL TARGETS IN EBV EPITHELIAL CANCERS

This study identifies CDC7 and POU2F1 as direct targets of EBNA1 in EBV+ epithelial cancers using VK1727 inhibition, revealing new therapeutic strategies.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.

A high-throughput, microplate reader-based method to monitor in vitro HIV latency reversal in the absence of flow cytometry

This paper introduces a microplate reader-based method to detect HIV latency reversal in J-Lat cells without flow cytometry, identifying new latency-reversing agents.

Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis

This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.