Novel Master Regulators of Microglial Phagocytosis and Repurposed FDA-approved Drug for Treatment of Alzheimer Disease
Kuixi Zhu, Qianying He, Sheng‐Feng Tsai, Dinusha C. Maheepala, Marc Henrion, Syed Shujaat Ali Zaidi, Branden Lau, Andrew Tang, Mika P. Cadiz, Rachel Hodos-Nkhereanye, Sara Moein, Melissa L. Alamprese, David Alan Bennett, Philip L. De Jager, John D. Frye, , Rui R. Chang
The paper identifies key driver genes for microglial phagocytosis and repurposes riluzole to treat Alzheimer's Disease by enhancing SLC1A2 activity.
bioRxiv · Oct 19, 2022 · PreprintNeuroscience