Author

Melissa L. Alamprese

University of ArizonaORCID 0000-0002-5290-1789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

David Alan BennettiD· 3 shared Kuixi ZhuiD· 3 shared Marc HenrioniD· 3 shared Nilüfer Ertekin‐TaneriD· 3 shared Rui R. ChangiD· 3 shared Sara Moein· 3 shared Branden Lau· 2 shared Philip L. De JageriD· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

David Alan BennettORCID

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3 papers

Recent·Most cited

Predictive Network Analysis Identifies JMJD6 and Other Novel Key Drivers in Alzheimer Disease

Julie P. Merchant, Kuixi Zhu, Marc Henrion, Syed Shujaat Ali Zaidi, Branden Lau, Sara Moein, Melissa L. Alamprese, Richard V. Pearse, David Alan Bennett, Nilüfer Ertekin‐Taner, Tracy L. Young‐Pearse, Rui R. Chang

The paper identifies JMJD6 and other key drivers of Alzheimer's disease using predictive network analysis and validates their effects on amyloid-beta and tau pathology in human neurons.

bioRxiv · Oct 19, 2022 · PreprintNeuroscience

Novel Master Regulators of Microglial Phagocytosis and Repurposed FDA-approved Drug for Treatment of Alzheimer Disease

Kuixi Zhu, Qianying He, Sheng‐Feng Tsai, Dinusha C. Maheepala, Marc Henrion, Syed Shujaat Ali Zaidi, Branden Lau, Andrew Tang, Mika P. Cadiz, Rachel Hodos-Nkhereanye, Sara Moein, Melissa L. Alamprese, David Alan Bennett, Philip L. De Jager, John D. Frye, , Rui R. Chang

The paper identifies key driver genes for microglial phagocytosis and repurposes riluzole to treat Alzheimer's Disease by enhancing SLC1A2 activity.

bioRxiv · Oct 19, 2022 · PreprintNeuroscience

Single Cell-type Integrative Network Modeling IdentifiedNovel Microglial-specific Targets for the Phagosome inAlzheimer's disease

Kruti Rajan Patel, Kuixi Zhu, Marc Henrion, Noam D. Beckmann, Sara Moein, Melissa L. Alamprese, Mariet Allen, Xue Wang, Gail Chan, Thomas Pertel, Parham Nejad, Joseph S. Reddy, Minerva M. Carrasquillo, David Alan Bennett, Nilüfer Ertekin‐Taner, , Rui R. Chang

The paper develops a computational systems biology approach to identify novel microglial-specific targets for the phagosome in Alzheimer's disease using integrated transcriptome and genotype data.

bioRxiv · Jun 9, 2020 · PreprintSystems Biology