Author

John Lyle Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Aaron G. MauleiD· 4 shared Rebecca ArmstrongiD· 4 shared Duncan WellsiD· 3 shared Emily RobbiD· 3 shared Nikki J. MarksiD· 3 shared Paul M. SelzeriD· 3 shared Paul McCuskeriD· 3 shared Andreas Krasky· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMolecular Biology

Aaron G. MauleORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Rebecca Armstrong, Duncan Wells, Emily Robb, Paul McVeigh, Andreas Krasky, John Lyle Harrington, Paul M. Selzer, Nikki J. Marks, Aaron G. Maule

This study identifies polo-like kinase 1 (fhplk1) as a key regulator of growth in juvenile Fasciola hepatica by showing its role in stem cell proliferation and cell cycle control.

PLoS Pathogens · Dec 2, 2025Peer-reviewedMolecular Biology

Serotonin signaling modulates growth and motility in juvenile Fasciola hepatica

Emily Robb, Sarah Muise, Lana Watt, Rebecca Armstrong, Duncan Wells, Paul McCusker, John Lyle Harrington, Andreas Krasky, Paul M. Selzer, Nikki J. Marks, Aaron G. Maule

This paper investigates the role of serotonin signaling in juvenile Fasciola hepatica, showing it modulates motility and growth through specific receptor mechanisms.

bioRxiv · Oct 2, 2025 · PreprintMolecular Biology

Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development

Rebecca Armstrong, Nikki J. Marks, Timothy G. Geary, John Lyle Harrington, Paul M. Selzer, Aaron G. Maule

This study identifies Wnt/β-catenin signaling as critical for juvenile Fasciola hepatica growth and development, with pharmacological inhibition showing potential for novel therapeutic strategies.

bioRxiv · Sep 4, 2024 · PreprintDevelopmental Biology

Neoblast-like Stem Cells of Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Erica Gardiner, Rebecca Armstrong, Erin M. Mccammick, Paul McVeigh, Emily Robb, Duncan Wells, Madelyn Nowak-Roddy, Abdullah Albaqami, Angela Mousley, Jonathan A. Coulter, John Lyle Harrington, Nikki J. Marks, Aaron G. Maule

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

bioRxiv · Dec 15, 2023 · PreprintMolecular Biology