Paul McCusker

This study identifies polo-like kinase 1 (fhplk1) as a key regulator of growth in juvenile Fasciola hepatica by showing its role in stem cell proliferation and cell cycle control.

This paper investigates the role of serotonin signaling in juvenile Fasciola hepatica, showing it modulates motility and growth through specific receptor mechanisms.

This study investigates the transcriptional effects of meclonazepam on Schistosoma mansoni, showing it causes tegument damage and apoptosis, with gene expression patterns similar to but distinct from praziquantel.

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

This paper identifies 146 GPCRs in Fasciola hepatica, including 18 unique rhodopsins, and provides ligand-receptor predictions, offering potential targets for new anthelmintic drugs.