Angela Mousley

This study identifies 2143 flp-genes across 100+ nematode species, revealing evolutionary patterns and expression dynamics of FLPs in parasitic nematodes.

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

This study introduces a novel computational pipeline to discover antimicrobial peptides (AMPs) in helminths, revealing unique AMP-like peptides and highlighting their potential as novel antimicrobials.

This study identifies 5887 AMP-encoding genes across 134 nematode genomes, revealing diverse AMP profiles influenced by lifestyle and clade, with implications for drug discovery.

This study uses in silico analyses to characterize endocannabinoid signaling across nematodes, revealing conservation patterns and potential drug targets in parasitic species.

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

The paper identifies conserved neuropeptides and their encoding genes in parasitic nematodes and characterizes their physiological activity on reproductive musculature.

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

The paper identifies extrasynaptic volume transmission as a non-synaptic signaling route in nematodes, showing that neuropeptides in pseudocoelomic fluid modulate reproductive function and behavior.

This paper identifies 146 GPCRs in Fasciola hepatica, including 18 unique rhodopsins, and provides ligand-receptor predictions, offering potential targets for new anthelmintic drugs.