Nikki J. Marks

Serotonin signaling modulates growth and motility in juvenile Fasciola hepatica

This paper investigates the role of serotonin signaling in juvenile Fasciola hepatica, showing it modulates motility and growth through specific receptor mechanisms.

Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development

This study identifies Wnt/β-catenin signaling as critical for juvenile Fasciola hepatica growth and development, with pharmacological inhibition showing potential for novel therapeutic strategies.

Neoblast-like Stem Cells of Fasciola hepatica

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

Developmental regulation and functional prediction of microRNAs in an expanded Fasciola hepatica miRNome

This paper expands the Fasciola hepatica miRNome by identifying 61 new miRNAs and provides the first developmental expression profiles and functional annotations of miRNAs in this parasite.

Transcriptomic analysis reveals a role for the nervous system in regulating growth and development of Fasciola hepatica juveniles

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes

The paper identifies conserved neuropeptides and their encoding genes in parasitic nematodes and characterizes their physiological activity on reproductive musculature.

RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

Extrasynaptic volume transmission: A novel route for neuropeptide signaling in nematodes

The paper identifies extrasynaptic volume transmission as a non-synaptic signaling route in nematodes, showing that neuropeptides in pseudocoelomic fluid modulate reproductive function and behavior.

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

This paper identifies 146 GPCRs in Fasciola hepatica, including 18 unique rhodopsins, and provides ligand-receptor predictions, offering potential targets for new anthelmintic drugs.