Author

Nathan G. Clarke

Queen's University Belfast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aaron G. MauleiD· 4 shared Emily RobbiD· 4 shared Paul McCuskeriD· 4 shared Paul McVeighiD· 4 shared Angela MousleyiD· 3 shared Duncan WellsiD· 3 shared Erin M. MccammickiD· 3 shared Nikki J. MarksiD· 3 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Aaron G. MauleORCID

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4 papers

Recent·Most cited

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Rebecca Armstrong, Duncan Wells, Emily Robb, Paul McVeigh, Andreas Krasky, John Lyle Harrington, Paul M. Selzer, Nikki J. Marks, Aaron G. Maule

This study identifies polo-like kinase 1 (fhplk1) as a key regulator of growth in juvenile Fasciola hepatica by showing its role in stem cell proliferation and cell cycle control.

PLoS Pathogens · Dec 2, 2025Peer-reviewedMolecular Biology

Neoblast-like Stem Cells of Fasciola hepatica

Paul McCusker, Nathan G. Clarke, Erica Gardiner, Rebecca Armstrong, Erin M. Mccammick, Paul McVeigh, Emily Robb, Duncan Wells, Madelyn Nowak-Roddy, Abdullah Albaqami, Angela Mousley, Jonathan A. Coulter, John Lyle Harrington, Nikki J. Marks, Aaron G. Maule

This paper identifies and characterizes neoblast-like stem cells in Fasciola hepatica, showing their self-renewal, differentiation, and radiation sensitivity, and identifies potential drug targets.

bioRxiv · Dec 15, 2023 · PreprintMolecular Biology

Transcriptomic analysis reveals a role for the nervous system in regulating growth and development of Fasciola hepatica juveniles

Emily Robb, Erin M. Mccammick, Duncan Wells, Paul McVeigh, Erica Gardiner, Rebecca Armstrong, Paul McCusker, Angela Mousley, Nathan G. Clarke, Nikki J. Marks, Aaron G. Maule

This study compares transcriptomic profiles of in vitro and in vivo maintained Fasciola hepatica juveniles to identify gene expression differences that may explain growth and development variations.

bioRxiv · Jan 13, 2022 · PreprintMolecular Biology

RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development

Paul McCusker, Wasim Hussain, Paul McVeigh, Erin M. Mccammick, Nathan G. Clarke, Emily Robb, Fiona M. McKay, Peter M. Brophy, David J. Timson, Angela Mousley, Nikki J. Marks, Aaron G. Maule

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

International Journal for Parasitology Drugs and Drug Resistance · Aug 19, 2020Peer-reviewedMolecular Biology