Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of NOGGIN-BMP Axis
Shingo Suzuki, Nicole Sandoval, Shnutez Doddipalli, Dalia M. Hassan, Cristina Barillá, András Rab, Mo-Fan Huang, John M. Avila, Barbara Tabak, Junjie Lu, Peggy P. Hsu, Tristan Frum, Bryan C. Derebery, María José Gacha Garay, Andres D. Chamorro-Parejo, , Sarah X.L. Huang
This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.
bioRxiv · Oct 1, 2025 · PreprintCell Biology