María José Gacha Garay

Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts

The paper shows that inhibiting apoptosis of alveolar myofibroblasts (AMFs) reprograms them into ductal myofibroblasts (DMFs) in a mouse model, suggesting fate plasticity in lung mesenchymal cells.

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of NOGGIN-BMP Axis

This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.

Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts

The paper classifies mouse lung mesenchymal cells into three axes using single-cell RNA-seq and imaging, identifying two myofibroblast populations with distinct markers and developmental fates.