STARR-CRAAVT: A platform to design cell type-specific regulatory elements for next-generation gene therapy
Robert Becker, Priyanka Choudhury, Martin Oti, Youssef Fouani, Benjamin Strobel, Stephanie Ketterer, Simon Rumpel, John Park, Sebastian Kreuz, Udo Maier, Stefan Michelfelder, Christian Schön
This study introduces STARR-CRAAVT, a platform to identify cell type-specific enhancers for gene therapy, showing promoter preference and enhancer positioning significantly affect activity.
bioRxiv · Jun 4, 2025 · PreprintGenomics