Author

John R. Otilano

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

David C. WilkesiD· 3 shared Juan Miguel MosqueraiD· 3 shared Jyothi ManohariD· 3 shared Majd Al AssaadiD· 3 shared Michael SigourosiD· 3 shared Olivier ElementoiD· 3 shared Abigail S. KingiD· 2 shared Allyson J. OceaniD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

David C. WilkesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

Alexandre Pellan Cheng, Itai Rusinek, Aaron Sossin, Adam J. Widman, Eti Meiri, Gat Krieger, Ori Hirschberg, Doron Shem Tov, Shlomit Gilad, Ariel Jaimovich, Omer Barad, Sammantha Avaylon, Srinivas Rajagopalan, Abigail G. Thress, Catherine J. Potenski, , Dan Avi Landau

This paper introduces ppmSeq, a sequencing technology that improves accuracy and efficiency in detecting SNVs by sequencing both DNA strands, showing superior performance in clinical applications like ctDNA detection.

bioRxiv · Aug 11, 2025 · PreprintGenomics

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

Hui–Hsuan Kuo, Bhavneet Bhinder, Hamza Numan Gokozan, Kathryn Gorski, Pooja Chandra, Jyothi Manohar, Daniela E. Guevara, John R. Otilano, Jenna E. Moyer, Marvel Tranquille, Sarah E. Ackermann, Jared A. Capuano, Cynthia Cheung, Thomas Anthony Caiazza, Phoebe L. Reuben, , M. Laura Martín

This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.

bioRxiv · Apr 10, 2025 · PreprintCancer Biology

Whole Genome Landscape Analysis of Homologous Recombination Deficiency in a Pan-Cancer Cohort

Majd Al Assaad, Kevin Hadi, Max Fine Levine, Daniela E. Guevara, Minal A. Patel, Marvel Tranquille, Abigail S. King, John R. Otilano, Alissa Semaan, Gunes Gundem, Juan Santiago Medina-Martinez, Michael Sigouros, Jyothi Manohar, Hui–Hsuan Kuo, David C. Wilkes, , Juan Miguel Mosquera

The paper analyzes whole-genome sequencing data from a pan-cancer cohort to define HRD, showing it extends beyond BRCA1/2 mutations and highlights the benefits of WGS over commercial assays for HRD detection.

medRxiv · Jun 28, 2024 · PreprintGenetic & Genomic Medicine