CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function
Apurva Tadimari Prabhakar, Claire D. James, Dipon Das, Raymonde O. Otoa, M.W. Day, John W. Burgner, Christian T. Fontan, Xu Wang, Andreas Wieland, Mary Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
This paper shows that CK2 phosphorylation of HPV16 E2 on serine 23 promotes interaction with TopBP1, which is critical for plasmid retention and HPV16 immortalization of keratinocytes.
bioRxiv · Feb 17, 2021 · PreprintMolecular Biology