Raymonde O. Otoa

Interaction with TopBP1 mediates human papillomavirus 16 E2 plasmid segregation/retention function and stability during the viral life cycle

This study shows that HPV16 E2 protein interacts with TopBP1 to mediate plasmid segregation and stability during the viral life cycle, and that this interaction is essential for E2 expression and function.

A critical role for E2-p53 interaction during the human papillomavirus 16 life cycle

This study shows that the E2-p53 interaction is critical for HPV16 life cycle, with disruption leading to anti-viral effects like reduced proliferation and increased DNA damage.

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function

This paper shows that CK2 phosphorylation of HPV16 E2 on serine 23 promotes interaction with TopBP1, which is critical for plasmid retention and HPV16 immortalization of keratinocytes.

Werner syndrome protein (WRN) regulates cell proliferation and the human papillomavirus 16 life cycle during epithelial differentiation

This study shows WRN regulates cell proliferation and HPV16 life cycle in epithelial differentiation by controlling DNA replication and DNA damage.

Human papillomavirus 16 E6 and E7 synergistically repress innate immune gene transcription

This study shows that HPV16 E6 and E7 proteins synergistically repress innate immune gene expression in the context of the full HPV16 genome, with neither protein alone sufficient for repression.