TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models
Edward N. Wilson, Congcong Wang, Michelle S. Swarovski, Kristy A. Zera, Hannah E. Ennerfelt, Qian Wang, Aisling M. Chaney, Esha Gauba, Javier A. Ramos Benitez, Yann Le Guen, Paras Singh Minhas, Maharshi Panchal, Yuting J. Tan, Eran Blacher, Chinyere Agbaegbu Iweka, , Katrin I. Andreasson
This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.
bioRxiv · Mar 5, 2024 · PreprintNeuroscience