Kristy A. Zera

ABERRANT HIPPOCAMPAL NEUROGENESIS IS A CONSERVED RESPONSE TO STROKE IN MICE: A MULTI-CENTER MULTIMODEL STUDY

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Blood-brain barrier dysfunction predicts cognitive trajectory after ischemic stroke

The paper identifies a plasma proteomic signature linked to blood-brain barrier dysfunction, which predicts cognitive decline after ischemic stroke.

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

Blockade of VCAM1 or VLA4 preserves cerebrovasculature and prevents cognitive decline late after stroke

This study shows that blocking VCAM1 or VLA4 after stroke preserves vascular integrity and prevents cognitive decline by promoting blood vessel growth and restoring the blood-brain barrier.

Juvenile mice are susceptible to infarct-induced neurodegeneration that causes delayed cognitive decline in a new model of pediatric ischemic stroke

This study develops a mouse model of pediatric ischemic stroke showing delayed cognitive decline and chronic neuroinflammation in uninjured brain regions in juvenile mice.

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models

This study shows that TREM1 deficiency prevents age-related myeloid metabolic changes and cognitive decline in Alzheimer's disease models.