Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors
Indra Bekere, Sören Rob, Jonas Lübbe, Susanne Kulnik, Laura Berneking, Jiabin Huang, Marie Schnapp, Björn‐Philipp Diercks, Andreas H. Guse, Alexander Carsten, Klaus Ruckdeschel, Martin Aepfelbacher
This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.
mBio · Nov 24, 2025Peer-reviewedCell Biology