Author

Klaus Ruckdeschel

University Medical Center Hamburg-EppendorfORCID 0000-0002-0164-9085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jiabin HuangiD· 2 shared Martin AepfelbacheriD· 2 shared Alexander CarsteniD· 1 shared Andreas H. GuseiD· 1 shared Björn‐Philipp DiercksiD· 1 shared Indra BekereiD· 1 shared Jiline Brinkmann· 1 shared Jonas Lübbe· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMicrobiology

Jiabin HuangORCID

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2 papers

Recent·Most cited

Genes controlling polysaccharide synthesis, protein folding and basic metabolism ensure intra-host cell adaptation and replication of Yersinia enterocolitica

Jiline Brinkmann, Jiabin Huang, Patrick Blümke, Martin Aepfelbacher, Klaus Ruckdeschel

This study identifies genes critical for Yersinia enterocolitica's intracellular replication by screening metabolic and structural pathways in host cells.

bioRxiv · Oct 14, 2026 · PreprintMicrobiology

Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

Indra Bekere, Sören Rob, Jonas Lübbe, Susanne Kulnik, Laura Berneking, Jiabin Huang, Marie Schnapp, Björn‐Philipp Diercks, Andreas H. Guse, Alexander Carsten, Klaus Ruckdeschel, Martin Aepfelbacher

This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.

mBio · Nov 24, 2025Peer-reviewedCell Biology