Jiabin Huang

Genes controlling polysaccharide synthesis, protein folding and basic metabolism ensure intra-host cell adaptation and replication of Yersinia enterocolitica

This study identifies genes critical for Yersinia enterocolitica's intracellular replication by screening metabolic and structural pathways in host cells.

Variant-specific nucleocapsid mutations shape host innate immune trajectories during SARS-CoV-2 infection

The paper investigates how specific mutations in the SARS-CoV-2 N/ORF9b gene affect host immune responses and infection outcomes using recombinant viruses.

Multi-omics characterization of extracellular vesicles derived from virus-positive Merkel cell carcinoma cells

This study characterizes the multi-omics profile of extracellular vesicles from MCPyV-positive Merkel cell carcinoma cells, revealing distinct molecular cargo and pathway enrichment.

DrtA, a novel major facilitator superfamily transporter, contributes to intrinsic tolerance to the chemotherapeutic agent mitomycin C in Acinetobacter baumannii

This study identifies DrtA, an MFS transporter in A. baumannii, as contributing to tolerance of mitomycin C and other compounds, with context-dependent roles influenced by efflux system redundancy.

Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.

Complex Human hear bearing Skin Organoids reveal Cell Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1

This study uses human hair-bearing skin organoids to investigate HSV-1 infection and host responses, revealing cell-type-specific susceptibility and spatially organized immune reactions.

Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling

This study identifies a novel function of MCPyV small T antigen in suppressing the type I interferon response by reducing IRF9 levels, impacting immune evasion and tumor progression.