Yajie Zhu

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells

This study shows that variant U1 snRNAs affect gene expression and cell cycle in human iPS cells through alternative splicing changes.

LoopBin, a VaDE-based neural network for chromatin loop classification

LoopBin classifies chromatin loops using a VaDE neural network, identifying distinct functional subgroups from 3D genomics data with minimal input.

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.