Athanasia Stavropoulou

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

The genome organizer SMC1A mediates the gene expression response in inflammation by dissociating from nuclear-speckles and redistributing to the nuclear periphery

This study shows that SMC1A redistributes from nuclear speckles to the nuclear periphery during inflammation, affecting gene expression through changes in splicing and mRNA processing.

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer

This study identifies Notch3 as a regulator of pericyte phenotypic plasticity in colorectal cancer, showing its role in promoting proliferation and altering contractile properties.

High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblasts

This study characterizes and spatially annotates normal and cancer-associated colon fibroblasts using single-cell RNA-sequencing and spatial transcriptomics.

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

Distinct chromosomal niches in the genome of S. cerevisiae provide the background for genomic innovation and shape the fate of gene duplicates

The paper investigates positional preferences of gene duplicates in S. cerevisiae, finding SSD and WGD genes occupy distinct chromosomal niches with different structural and regulatory features.