Author

Jonathan Schmitz

Vanderbilt University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Organism:multiple species· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam S. LauringiD· 1 shared Alexandra M. MellisiD· 1 shared Carlos Gabriel GrijalvaiD· 1 shared Derek E. DimcheffiD· 1 shared Emily E. BendalliD· 1 shared Emily Toth MartiniD· 1 shared Erich Bornberg-BaueriD· 1 shared H. Keipp TalbotiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

Adam S. LauringORCID

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2 papers

Recent·Most cited

In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants

Emily E. Bendall, Derek E. Dimcheff, Leigh Papalambros, William J. Fitzsimmons, Yuwei Zhu, Jonathan Schmitz, Natasha Halasa, James D. Chappell, Emily Toth Martin, Jessica E. Deyoe, Sarah E. Smith-Jeffcoat, Melissa A R Rolfes, Alexandra M. Mellis, H. Keipp Talbot, Carlos Gabriel Grijalva, Adam S. Lauring

This study uses longitudinal sequencing of a household cohort to analyze within-host SARS-CoV-2 dynamics, finding rare positive selection in spike and genetic hitchhiking between synonymous and nonsynonymous variants.

PLoS Pathogens · Apr 28, 2025Peer-reviewedMicrobiology

De Novo Genes are "Frozen Accidents" whichEscaped Rapid Turnover of Pervasively TranscribedORFs

Jonathan Schmitz, Kristian Ullrich, Erich Bornberg-Bauer

The paper investigates de novo gene emergence and finds that novel ORFs are rapidly lost, with only length and nucleotide composition changing over time, suggesting they are functional 'frozen accidents'.

bioRxiv · Jul 21, 2017 · PreprintEvolutionary Biology