Author

Sarah E. Smith-Jeffcoat

Centers for Disease Control and PreventionORCID 0000-0002-7962-9017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam S. LauringiD· 1 shared Alexandra M. MellisiD· 1 shared Carlos Gabriel GrijalvaiD· 1 shared Derek E. DimcheffiD· 1 shared Emily E. BendalliD· 1 shared Emily Toth MartiniD· 1 shared H. Keipp TalbotiD· 1 shared James D. ChappelliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Adam S. LauringORCID

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1 paper

Recent·Most cited

In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants

Emily E. Bendall, Derek E. Dimcheff, Leigh Papalambros, William J. Fitzsimmons, Yuwei Zhu, Jonathan Schmitz, Natasha Halasa, James D. Chappell, Emily Toth Martin, Jessica E. Deyoe, Sarah E. Smith-Jeffcoat, Melissa A R Rolfes, Alexandra M. Mellis, H. Keipp Talbot, Carlos Gabriel Grijalva, Adam S. Lauring

This study uses longitudinal sequencing of a household cohort to analyze within-host SARS-CoV-2 dynamics, finding rare positive selection in spike and genetic hitchhiking between synonymous and nonsynonymous variants.

PLoS Pathogens · Apr 28, 2025Peer-reviewedMicrobiology