TRPM7 Annexin A1 Mechanosensitive Pathway Drives Capillary Infiltration by Circulating Tumor Cells
Lanfeng Liang, Zhifeng Zhao, Jonathan Wei Bao Chua, Yun Chen, Xiao Song, Lina H. K. Lim, Jiamin Wu, Qionghai Dai, Andrew W. Holle, Chwee Teck Lim
The paper identifies a TRPM7-Annexin A1 pathway that enables circulating tumor cells to adapt to fluid shear stress in capillaries, facilitating metastasis.
bioRxiv · Aug 1, 2025 · PreprintCancer Biology