Andrew W. Holle

This study shows that differences in electrostatic potential between heterochromatin and euchromatin affect nucleosome stability and transcription factor access, explaining transcriptional differences.

This paper develops a microfluidic platform to study macrophage-adipocyte interactions by overcoming density mismatch, revealing macrophage dynamics in clearing adipocytes and forming Crown-Like Structures.

This study investigates mechanical memory in cells, showing that stiffness-sensitive cells improve confined migration after prior exposure to soft substrates, mediated by NFATC2.

The paper uses nondimensional nucleus shape parameters to infer molecular changes during confined cell migration, revealing mechanostasis in response to confinement.

The paper identifies a TRPM7-Annexin A1 pathway that enables circulating tumor cells to adapt to fluid shear stress in capillaries, facilitating metastasis.