A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer
Jaekwang Jeong, Jongwon Lee, Seungsoo Kim, Jaechul Lim, Jaehun Shin, Kwangmin Yoo, Jonghun Kim, Yoshiaki Tanaka, Hyun Seop Tae, Lark Kyun Kim, In-Hyun Park, Samir Zaidi, John Wysolmerski, Jungmin Choi
This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.
bioRxiv · Apr 16, 2024 · PreprintCancer Biology