Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model
Christopher D. Balak, Johannes C. M. Schlachetzki, Addison J. Lana, Elizabeth West, Christine Hong, Jordan DuGal, Yi Zhou, Benjamin C. Li, Payam A. Saisan, Nathanael J. Spann, Vishal Sarsani, Martina P. Pasillas, Sydney O’Brien, Philip L.S.M. Gordts, Beth Stevens, , Christopher K. Glass
This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.
bioRxiv · Nov 12, 2024 · PreprintNeuroscience