Author

Payam A. Saisan

University of California San DiegoORCID 0009-0003-9422-7643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Addison J. LanaiD· 1 shared Anders Martin DaleiD· 1 shared Anna DevoriD· 1 shared Baoqiang LiiD· 1 shared Benjamin C. LiiD· 1 shared Beth StevensiD· 1 shared Christine Hong· 1 shared Christopher D. BalakiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Addison J. LanaORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintApr 30, 2026

Molecular Translators as a Computational Primitive for Biomarker Discovery: Learnability Gains Under Conserved Information Ceilings

Payam A. Saisan, Sandip Pravin Patel

The paper develops a framework to analyze performance plateaus in H&E-to-molecular biomarker translation, distinguishing methodological limitations from intrinsic information ceilings.

DOI 10.64898/2026.04.27.720188

spatial transcriptomicsstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 12, 2024

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

Christopher D. Balak, Johannes C. M. Schlachetzki, Addison J. Lana…·Christopher K. Glass

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

3 citations

mousescRNA-seq

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NeurosciencebioRxivPreprintOct 13, 2021

Microscopic Quantification of Oxygen Consumption across Cortical Layers

Philipp Mächler, Natalie Fomin-Thunemann, Martin Thunemann…·Anna Devor

The paper measures oxygen consumption across cortical layers in awake mice and finds a decrease in baseline CMRO2 from layer I to IV, accompanied by increased tissue oxygenation.

6 citations

mouseimaging

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