Author

Christine Hong

Ionis Pharmaceuticals (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Fredrik KammeiD· 2 shared Adamantia F. FragopoulouiD· 1 shared Addison J. LanaiD· 1 shared Adriana‐Natalia MurgociiD· 1 shared Ahmed M. OsmaniD· 1 shared Alexander GoginashviliiD· 1 shared Alexander MonelliD· 1 shared Anastasios E. DamdimopoulosiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

Fredrik KammeORCID

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Author profile →

3 papers

Recent·Most cited

Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype.

Mathilde Cheray, Adriana‐Natalia Murgoci, Adamantia F. Fragopoulou, Carlos Fernando Dias Rodrigues, Martin Škandík, Ahmed M. Osman, Christine Hong, Guillermo Vázquez-Cabrera, Lara Frieß, Lena-Maria Carlson, Shigeaki Kanatani, Yue Li, Anastasios E. Damdimopoulos, Per Uhlén, Fredrik Kamme, , Bertrand Joseph

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

bioRxiv · Feb 22, 2025 · PreprintImmunology

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

Christopher D. Balak, Johannes C. M. Schlachetzki, Addison J. Lana, Elizabeth West, Christine Hong, Jordan DuGal, Yi Zhou, Benjamin C. Li, Payam A. Saisan, Nathanael J. Spann, Vishal Sarsani, Martina P. Pasillas, Sydney O’Brien, Philip L.S.M. Gordts, Beth Stevens, , Christopher K. Glass

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

bioRxiv · Nov 12, 2024 · PreprintNeuroscience

Re-activation of neurogenic niches in aging brain

Roy Maimon, Carlos Chillón-Marinas, Sonia Vazquez‐Sanchez, Colin Kern, Ignatius Jenie, Kseniya Malukhina, Stephen R. Moore, Jess Cui, Alexander Goginashvili, Siavash Moghadami, Alexander Monell, Melissa McAlonis‐Downes, Christine Hong, Paymaan Jafar‐Nejad, C. Frank Bennett, , Bogdan Bintu

This paper demonstrates that transient suppression of PTBP1 in aged glial cells can re-activate neurogenesis in murine and human brains, generating new neurons through canonical pathways.

bioRxiv · Jan 27, 2024 · PreprintNeuroscience