Nathanael J. Spann

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-inducedlung injury

The paper identifies TREM2-p53 signaling as a determinant of oxygen-induced lung injury in mice, showing that TREM2 loss reduces inflammation and improves lung development.

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms

The paper analyzes how genetic variation affects gene expression and epigenetics in Kupffer cells, distinguishing between cell intrinsic and environment-dependent mechanisms.

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

The paper identifies non-redundant DNA binding activities of AP-1 family members in macrophages using ChIP-sequencing and machine learning, showing motif ensembles drive factor-specific binding.