Christopher D. Balak

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.

The paper identifies genes associated with Rett syndrome-like (RTT-L) phenotype through whole exome sequencing and protein-protein interaction network analysis, revealing shared pathways with classical Rett syndrome.