RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.
Raúl Ernesto Flores González, Christophe Gonçalves, Noah Wirasinghe, Véronique Gaudreault, José Ferro, Kelly Coutant, Andrew Mitchell, Theodore Papadopoulos, Y. G. Cho, Elizabeth M. Guettler, Daniel González‐Moreno, Samuel E.J. Preston, Feiyang Cai, Natascha Gagnon, Steve Jean, , Sonia Victoria Del Rincon
This study identifies RAB1A as a vulnerability in uveal melanoma through dual inhibition of MNK1/2 and mTOR, showing it disrupts protein trafficking and blocks liver metastasis.
Cell Death and Differentiation · Feb 18, 2026Peer-reviewedCancer Biology