Véronique Gaudreault

NanoCutSight is a nanopore sequencing pipeline to quantify indels and identify modification types in genome editing, benchmarked on guide RNAs in cell and organoid models.

This study identifies RAB1A as a vulnerability in uveal melanoma through dual inhibition of MNK1/2 and mTOR, showing it disrupts protein trafficking and blocks liver metastasis.

The paper uses proximity labeling to identify proteins interacting with 23 human RAB GTPases, revealing novel functional connections and interactions.

The paper shows that inhibiting autophagy in intestinal stem cells increases enteroendocrine cell differentiation via Stat92E activity in Drosophila.