Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies
Natasha M. Clark, Nida K. Keles, Grace N. Hagedorn, Vadim A. Klenchin, Hanné Andersen, Jim Treece, Christine M. Fennessey, Jun Xie, Thomas N. Denny, C. Todd DeMarco, Jose S Hernandez, Saverio Capuano, Matthew R. Gardner, Brandon F. Keele, Guangping Gao, , David T. Evans
AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.
bioRxiv · Apr 23, 2026 · PreprintImmunology