Author

Natasha M. Clark

University of Wisconsin–MadisonORCID 0000-0002-3152-892XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2

Frequent Co-Authors

Brandon F. KeeleiD· 2 shared Christine M. FennesseyiD· 2 shared David T. EvansiD· 2 shared Guangping GaoiD· 2 shared Mario RoedereriD· 2 shared Matthew R. GardneriD· 2 shared Nida K. Keles· 2 shared Saverio CapuanoiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Brandon F. KeeleORCID

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2 papers

Recent·Most cited

Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies

Natasha M. Clark, Nida K. Keles, Grace N. Hagedorn, Vadim A. Klenchin, Hanné Andersen, Jim Treece, Christine M. Fennessey, Jun Xie, Thomas N. Denny, C. Todd DeMarco, Jose S Hernandez, Saverio Capuano, Matthew R. Gardner, Brandon F. Keele, Guangping Gao, , David T. Evans

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

bioRxiv · Apr 23, 2026 · PreprintImmunology

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Vadim A. Klenchin, Natasha M. Clark, Nida K. Keles, Saverio Capuano, Rosemarie D. Mason, Guangping Gao, Aimee Teo Broman, Emek Köse, Taina T. Immonen, Christine M. Fennessey, Brandon F. Keele, Jeffrey D. Lifson, Mario Roederer, Matthew R. Gardner, David T. Evans

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

Science Immunology · Feb 28, 2025Peer-reviewedImmunology