Effective macrophage clearance of Klebsiella pneumoniae requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidase
Alexis E. Wilcox, Elizabeth H. Madigan, Catherine J. Andres, Joseph D. Serewicz, Z. Ece Kilic, Tanya S. Freedman, Andrew J. Olive, Caitlyn L. Holmes
This study shows that macrophages clear Klebsiella pneumoniae via iNOS-mediated RNS, not NOX2-generated ROS, highlighting a key role for iNOS in bacterial clearance.
bioRxiv · Sep 10, 2026 · PreprintImmunology