Tanya S. Freedman

This study shows that macrophages clear Klebsiella pneumoniae via iNOS-mediated RNS, not NOX2-generated ROS, highlighting a key role for iNOS in bacterial clearance.

The paper tests a new peer-review model that separates scientific quality from impact, showing reviewers can effectively evaluate both dimensions and participants support its adoption.

The paper shows that LynA and LynB expression levels determine steady-state phosphorylation of Syk and SHIP1, limiting macrophage signaling without microbial stimulation.

The paper shows that both LynA and LynB restrict macrophage proliferation and drive TLR-induced ECM-remodeling and inflammatory cytokine production.

The paper shows that Lyn maintains steady-state phosphorylation of SHIP1, balancing Erk and Akt signaling in macrophages, and that phagocytic synapse formation bypasses this requirement.

This study shows that an ADAM17-blocking antibody enhances IL-15-mediated NK cell activation and proliferation through CD16A and CD137, with potential therapeutic applications in cancer.