Caitlyn L. Holmes

This study shows that macrophages clear Klebsiella pneumoniae via iNOS-mediated RNS, not NOX2-generated ROS, highlighting a key role for iNOS in bacterial clearance.

This paper develops a simulation-based metric to accurately interpret bacterial dissemination by distinguishing true dissemination from barcode confounding in barcoded bacteria studies.

This study identifies arginine as a key regulator of mucoidy in hypervirulent Klebsiella pneumoniae, showing it activates the rmpADC promoter and modulates capsular polysaccharide chain length, impacting immune evasion and in vivo fitness.

This study tracks Klebsiella pneumoniae dissemination from the lung using barcoding, revealing two distinct patterns of bacterial spread and their associated host and bacterial factors.

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

The paper integrates Tn-Seq fitness data with functional data to identify seven common fitness mechanisms across five Enterobacterales species, validating one gene's role in bacteremia and antibiotic resistance.

This study shows that type 2 diabetes mellitus enhances Klebsiella pneumoniae pathogenesis by increasing gut colonization and lung infection severity.