Author

Joseph DeSautelle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron Edward FosteriD· 2 shared Bradley HammersoniD· 2 shared Brian D. WeitzneriD· 2 shared Howell F. MoffettiD· 2 shared Kevin G. HaworthiD· 2 shared Marc J. LajoieiD· 2 shared Robert A. LanganiD· 2 shared Rupesh H. Amin· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Aaron Edward FosterORCID

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2 papers

Recent·Most cited

A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors

Rupesh H. Amin, Kevin G. Haworth, Howell F. Moffett, Jerry C. Chen, Lisa Park, Jason K. Yokoyama, Allan L. Wang, Leah J. Tait, Maria M. Steele, John T. Crowl, Thaddeus M. Davenport, Joseph DeSautelle, Jared Louis Hammer, Willimark Obenza, Vanessa R. Montoya, , Aaron Edward Foster

This paper designs a transgene that enhances CAR T cell persistence and tumor regression by integrating multiple engineered technologies in solid tumor models.

bioRxiv · Sep 24, 2026 · PreprintSynthetic Biology

Protein design to broadly reprogram engineered T cell function

Scott E. Boyken, Sean Merillat, Robert A. Langan, Howell F. Moffett, Brian Coventry, Françoise Haeseleer, Kevin G. Haworth, Inna Goreshnik, Joseph DeSautelle, John Chukinas, Bradley Hammerson, Thaddeus M. Davenport, Duy Nguyen, Rupesh H. Amin, Shujun Yuan, , Marc J. Lajoie

This paper designs proteins to reprogram T cell signaling pathways, improving CAR-T and TCR-T performance in solid tumor models.

bioRxiv · Aug 17, 2026 · PreprintSynthetic Biology