Shujun Yuan

A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors

This paper designs a transgene that enhances CAR T cell persistence and tumor regression by integrating multiple engineered technologies in solid tumor models.

A Dynamically Regulated Designed IL-2 for Tumor-localized Signaling

This paper designs a dynamically regulated IL-2 variant that enhances tumor-specific immune responses while reducing systemic toxicity.

Protein design to broadly reprogram engineered T cell function

This paper designs proteins to reprogram T cell signaling pathways, improving CAR-T and TCR-T performance in solid tumor models.