Protein design to broadly reprogram engineered T cell function
Scott E. Boyken, Sean Merillat, Robert A. Langan, Howell F. Moffett, Brian Coventry, Françoise Haeseleer, Kevin G. Haworth, Inna Goreshnik, Joseph DeSautelle, John Chukinas, Bradley Hammerson, Thaddeus M. Davenport, Duy Nguyen, Rupesh H. Amin, Shujun Yuan, , Marc J. Lajoie
This paper designs proteins to reprogram T cell signaling pathways, improving CAR-T and TCR-T performance in solid tumor models.
bioRxiv · Aug 17, 2026 · PreprintSynthetic Biology