Scott E. Boyken

A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors

This paper designs a transgene that enhances CAR T cell persistence and tumor regression by integrating multiple engineered technologies in solid tumor models.

A Dynamically Regulated Designed IL-2 for Tumor-localized Signaling

This paper designs a dynamically regulated IL-2 variant that enhances tumor-specific immune responses while reducing systemic toxicity.

Protein design to broadly reprogram engineered T cell function

This paper designs proteins to reprogram T cell signaling pathways, improving CAR-T and TCR-T performance in solid tumor models.

Computational design of nanoscale rotational mechanics in de novo protein assemblies

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

De novo design of modular and tunable allosteric biosensors

The paper designs modular biosensors using de novo protein switches that detect various analytes with high sensitivity and modularity.