Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph Dresser, Christian K. Werner, Hanshi Sun, Drew W. Pratt, Peter Sajjakulnukit, Shuang George Zhao, Mary A. Davis, Barbara Scott Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, , Daniel Richard Wahl
This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.
Nature Communications · Jul 30, 2020Peer-reviewedNeuroscience