Peter Sajjakulnukit

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

This study shows that GOT1 and GOT2 have opposing roles in rod photoreceptor health, with GOT2 acting as a neuroprotective factor under reductive stress conditions.

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

Reprogramming the Immune Suppressive Tumor Microenvironment in Glioma Enhances the Efficacy of Immune-Mediated Gene Therapy

This study shows that combining CD73 inhibition with immune-stimulatory gene therapy improves treatment efficacy for wtIDH1 gliomas.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

Synthetic Immunological Niche Reveals Early Immune Dysregulationand Stratifies Therapeutic Response in Type 1 Diabetes

The paper develops a synthetic immunological niche to identify early immune dysregulation and stratify therapeutic response in Type 1 Diabetes.

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis-Dependent Ferroptotic Vulnerability

This study identifies a metabolic vulnerability in colorectal cancer where combining HIF-2 inhibition with cholesterol biosynthesis inhibition using statins enhances ferroptosis, offering a new therapeutic strategy.

Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

A metabolic atlas of mouse aging

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

Aspartate transaminases are required for blood development

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

Gut sulfide metabolism modulates behavior and brain bioenergetics

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma

This study identifies a metabolic link between methionine metabolism, DNA repair, and radiation resistance in glioblastoma, showing that inhibiting SAM synthesis enhances radiation efficacy.

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

This study shows that purine metabolism affects DNA repair and therapy resistance in glioblastoma, suggesting that targeting purine synthesis could improve treatment outcomes.

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.

Meta-analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

The paper analyzes targeted metabolomics data from diverse biological samples to assess measurement quality and identify metabolite dynamics across conditions.