ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
Guinevere L. Grice, Eleanor Minogue, Hudson W. Coates, Mekdes Debela, Richard J Stopforth, Niek Wit, Zongyu Li, Joseph P. Crowley, Arthur Kaser, Nicole Kaneider-Kaser, Robin Antrobus, Marcia C. Haigis, Randall S. Johnson, James A. Nathan
This study identifies ABHD11 as a deglutarylating enzyme that regulates T cell metabolism by maintaining TCA cycle integrity through removal of glutaryl-lipoyl adducts.
Nature Chemical Biology · Jul 15, 2025Peer-reviewedCell Biology