Marcia C. Haigis

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

This study identifies a metabolic-epigenetic mechanism linking leucine catabolism to glycolysis that drives resistance to CDK4/6 inhibitors in ER+ breast cancer.

This study provides structural insights into DHODH catalysis and drug resistance by analyzing conformational changes and resistance mutations.

This study shows glutamine supports autoimmune disease in Foxp3 deficiency by fueling biosynthetic pathways in T and B cells, with distinct roles in cytokine production and autoantibody formation.

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

This study identifies glutamine antagonism as a therapeutic strategy for adrenocortical carcinoma by inhibiting de novo nucleotide biosynthesis and inducing DNA damage.

This study shows Tcf7l2 maintains hepatic zonation and glutamine homeostasis, with loss of Tcf7l2 causing metabolic disruption and decreased glutamine levels.

This study identifies ABHD11 as a deglutarylating enzyme that regulates T cell metabolism by maintaining TCA cycle integrity through removal of glutaryl-lipoyl adducts.

This study identifies and maps glioma-innervating neurons (GINs) using rabies virus tracing and reveals their distinct electrophysiological properties and integration into brain networks.

This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.

The paper shows NRF2 activation in KEAP1 wildtype lung cancers causes NADH-reductive stress, making them vulnerable to Complex I inhibition.

The paper introduces Compass, an algorithm that uses single-cell RNA-Seq and flux balance analysis to characterize metabolic states in Th17 cells, revealing a metabolic switch and novel anti-inflammatory regulators.

This study identifies METTL15 as the enzyme responsible for m4C839 methylation in human 12S mt-rRNA and shows its critical role in mitochondrial function.