Author

Joshua A. Frydman

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3

Frequent Co-Authors

Carolyn M. LorchiD· 3 shared Jessica L. Xia· 3 shared Lisa R. BeutleriD· 3 shared Nikolas W. HayesiD· 3 shared Haley S. Province· 2 shared Hayley E. McMorrowiD· 2 shared Stefan W. Fleps· 2 shared Esther TangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Carolyn M. LorchORCID

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3 papers

Recent·Most cited

IL-1β engages distinct peripheral sensory circuits to suppress feeding across time

Nikolas W. Hayes, Jessica L. Xia, Joshua A. Frydman, Marcos J. Duran, Kamil K. Gebis, Carolyn M. Lorch, Haley S. Province, Esther Tang, Lisa R. Beutler

This study identifies two distinct phases of IL-1β-induced anorexia mediated by different peripheral sensory circuits.

bioRxiv · Feb 24, 2026 · PreprintNeuroscience

Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetite

Hayley E. McMorrow, Carolyn M. Lorch, Nikolas W. Hayes, Stefan W. Fleps, Joshua A. Frydman, Jessica L. Xia, Ricardo J. Samms, Lisa R. Beutler

This study shows that incretin hormone analogs inhibit AgRP neuron activity to suppress appetite, with GIP playing a unique role in nutrient-mediated inhibition.

bioRxiv · Mar 18, 2024 · PreprintNeuroscience

Sucrose overconsumption impairs feeding circuit dynamics and promotes palatable food intake

Carolyn M. Lorch, Nikolas W. Hayes, Jessica L. Xia, Stefan W. Fleps, Hayley E. McMorrow, Haley S. Province, Joshua A. Frydman, Jones G. Parker, Lisa R. Beutler

This study shows that high-sucrose diets impair gut-brain communication by altering AgRP neuron activity, leading to increased palatable food intake.

Cell Reports · Jan 14, 2024Peer-reviewedNeuroscience